Dr. Tsukada Norimasa, Chief Director of the renowned institutions CLINIC 9ru, THE PREVENTION CLINIC TOKYO, and BiOSTYLE CLINIC. With him, we gain a fascinating insight into the future of prevention, lifestyle medicine, and modern health culture in Japan.
Andreas Conrad conducted an interview with the internationally respected physician about his vision of a holistic approach that goes far beyond traditional forms of treatment. The focus was on questions about the opportunities of preventive medicine, the latest developments in diagnostics and therapy, and how a healthy lifestyle can be sustainably promoted.
Exclusive interview with Dr. Tsukada Norimasa, Chief Director der CLINIC 9ru, THE PREVENTION CLINIC TOKYO und BiOSTYLE CLINIC
Andreas Conrad: Could you briefly explain how CLINIC 9ru, THE PREVENTION CLINIC TOKYO, and BiOSTYLE CLINIC collaborate to realize the medical concept of “5Star Medical Club” in Tokyo?
Dr. Tsukada Norimasa: CLINIC 9ru is a facility located in a luxury hotel space, offering advanced Japanese anti-aging treatments. We provide original treatment programs that combine self-stem cells, exosomes, blood cleansing, and other cutting-edge therapies. In addition, advanced skincare and skin regeneration treatments are also available.
THE PREVENTION CLINIC is a high-level medical check-up facility adjacent to CLINIC 9ru. By using MRI, CT, endoscopy, AI-based 3D imaging, and messenger RNA-based genetic testing, we can detect lesions that are often overlooked in conventional imaging. Together with CLINIC 9ru, we propose tailor-made treatment courses. We also collaborate with nearby specialized hospitals and provide identity guarantee services (for a fee) necessary for issuing medical visas.
BiOSTYLE CLINIC houses the largest GMP-level CPC in the area, where we culture the cells used in CLINIC 9ru.
Andreas Conrad: What distinguishes 5Star Medical Club Tokyo from other medical facilities, especially for VIP and international guests?
Dr. Tsukada Norimasa: We are the only institution that possesses all three components mentioned above. Furthermore, we are located inside a luxury hotel next to the Imperial Palace, the very center of Tokyo. With multilingual concierge and caseworker services, seamless cooperation with hotels and chauffeur services, as well as strong collaboration with specialized hospitals, we believe our services are on a different level.
Andreas Conrad: What role does preventive medicine play in your concept? How do you integrate elements such as genetic analysis, immune diagnostics, and regenerative medicine into daily patient care?
Dr. Tsukada Norimasa: Aging is the underlying cause not only of physical decline but also of lifestyle-related diseases such as cancer, diabetes, and rheumatism. By delaying or even reversing aging processes, we can minimize these risks and preserve youthful appearance as well as health.
Biologically, humans age daily, while at the same time, organs and vascular tissues constantly regenerate. Accelerated aging occurs when the pace of regeneration slows while aging cells accumulate, releasing aging factors that speed up deterioration. Removing these cells and factors is a key medical approach to slowing aging.
For new cells to be generated, stem cells, cytokines that command them, and the correct genetic blueprints are required. By strengthening these elements comprehensively, it becomes possible to halt aging. Our group continuously incorporates the latest, safest medical advancements, ensuring our treatments evolve alongside medical science.
Andreas Conrad: Your clinic seems to closely connect aesthetic medicine and regenerative medicine. How do you realize the combination of beauty and medical precision in clinical practice?
Dr. Tsukada Norimasa: We do not perform cosmetic procedures that alter one’s natural appearance. Instead, our aesthetic treatments focus on rejuvenating the skin. While traditional dermatology focused only on the epidermis, our approach addresses hydration, stimulates turnover with stem cells and growth factors, and reconstructs collagen fibers in the dermis through fibroblasts. This allows patients to regain the naturally youthful skin they once had—subtle in photos but clearly visible in person.
Andreas Conrad: How do international guests respond to your integrated concept that combines medicine, prevention, and lifestyle? Are there cultural differences in their reception?
Dr. Tsukada Norimasa: We find that wealthy international clients tend to be more concerned about health management and anti-aging than Japanese patients. They appreciate not only advanced medicine but also the membership-style service where various specialists are personally involved.
Furthermore, Japan is known as the world’s longest-living nation with top-level medical standards, which enhances the trust placed in us.
Andreas Conrad: In the development and innovation of regenerative medicine, what do you find most fascinating, and how are you applying it in practice?
Dr. Tsukada Norimasa: We are deeply interested in the mechanism by which microRNAs inside exosomes influence the characteristics of new cells. We are working to theoretically substantiate the clinical improvements observed when exosomes derived from healthy, young donors are introduced into patients suffering from disease or aging.
Animal studies have shown that specific microRNAs from bone marrow stem cell-derived exosomes can regenerate pancreatic beta cells in diabetic models. There are also human cases where such exosomes improved diabetes, and we are pursuing joint research with university hospitals to validate these findings.
Additionally, we are exploring applications of 5-ALA—a substance produced only in Japan—that enhances mitochondrial activity to advance treatments for cancer and dementia.
We would like to thank Dr. Tsukada Norimasa for his insightful answers.
FrontRowSociety editor-in-chief Andreas Conrad conducted the exclusive interview with Dr. Tsukada Norimasa, Chief Director of CLINIC 9ru, THE PREVENTION CLINIC TOKYO, and BiOSTYLE CLINIC, in September 2025.
Further information:
5Star Medical Club
The Peninsula Tokyo 4F
1-8-1 Yurakucho, Chiyoda-ku, Tokyo, 100-0006, Japan
